When New Orleans paramedics and longtime best friends Steve and Dennis are called to a series of bizarre and gruesome accidents, they chalk it up to a mysterious new drug found at the scene. But after Dennis’ oldest daughter disappears, Steve stumbles upon a terrifying truth about the supposed psychedelic that will challenge everything he knows about reality and the flow of time itself.

Friends reunite to play The Buddy Games, a wild assortment of absurd physical and mental challenges. In the process, they'll heal old wounds, right past wrongs, and figure out the true meaning of friendship.